Challenges and Failures of Vision Screenings

Vision screenings are defined as visual acuity screenings that are performed by non-eye care professionals.

Introduction

The primary purpose of vision screenings is to identify early signs of disease in order to implement early treatment and reduce the emergence of that disease. Screenings should only be done when they are proven to be beneficial. According to the World Health Organization (WHO), “screening is warranted for conditions that represent important health problems, for which the natural history is known, and for which suitable tests and accepted treatments in the early stages are available. The purpose is not to detect all cases with somewhat subnormal function, but, rather, to identify children for whom reduced vision is a significant problem, while avoiding unnecessary referrals of ‘normal’ children.”(1)  Similarly the United Kingdom (UK) National Screening Committee defines screening as “a public health service in which members of a defined population, who do not necessarily perceive that they are at risk of, or are already affected by, a disease or its complications, are asked a question or offered a test to identify those individuals who are more likely to be helped than harmed by further tests or treatments to reduce the risk of a disease or its complications.”(2)

The value of a screening test is determined by its ability to distinguish a diseased from a normal, non-diseased state. Whereas the screening test should ideally have 100% specificity, 100% sensitivity, and 100% positive predictive value (PPV), (3) there are no known vision screening tests with this level of accuracy. “Sensitivity is taken to be the probability that a test gives a positive result when a disorder is present. Specificity is the probability that a test gives a negative result when the person tested is healthy. For screening, however, the positive predictive value is important. This is the probability that a disorder is present when the test gives a positive result (the number of people correctly diagnosed as positive divided by the total number of true positives and false positives).” (4) Screenings can be conducted in many different settings, including pediatrician offices, health departments, schools, pharmacies, shopping malls, churches, and other community centers. “Although these trends are important in engaging communities in healthy behaviors, screening is not a substitute for regular contacts with a health care provider with whom the results should be shared, validated with a physical exam, and compared over time.”(5)

Lack of Evidence Basis For Vision Screenings

Though it is important to prevent vision loss by identifying diseases and problems early on, there is no evidence that screenings are effective or of any benefit.  “Vision screening is often advocated with little evidence of effectiveness simply because its benefits seem too obvious to question. Among school-age children, for example, there are no completed randomized trials of vision screening programs. For older people, among whom randomized trials have been undertaken, vision screening appears not to be an effective intervention….Better understanding of the barriers (at the person, family and provider level) is essential before strategies can be devised, and these strategies need to be evaluated carefully. Only then can we know if we are doing more good than harm and spending limited healthcare resources wisely.”(6)  In addition, a study conducted on the effectiveness of population screening for visual impairment in elderly people in the United Kingdom, found that “there were benefits, but these were not large enough to justify the introduction of population screening.”(7) Studies conducted on the effectiveness of population screening for visual impairment in young children also revealed the need for more conclusive evidence. A literature review on the benefit of vision screening in preschool children found that “the available data do not allow any firm conclusion about the efficacy and cost-effectiveness of preschool vision screening. Further clinical studies are needed to answer these questions.”(8) A screening for children with amblyopia was also found to be ineffective. For example, with an estimated 3% prevalence rate of amblyopia, a population of 700,000 children born in the same year would have a test sensitivity of 60%, a test specificity of 90%, and the positive predictive value is only 16%. This means that 16 of every 100 children are correctly referred to an ophthalmologist for further treatment, while the other 84 children were unnecessarily referred. The positive predictive value is low because the prevalence of amblyopia and the test sensitivity are low. Other tests for amblyopia also produced low positive predictive values. The Vision in Preschoolers Study tested 2,588 four-to-five year olds in 2004 for amblyopia using a variety of individual tests (random dot stereo tests, the Lea Vision Test, autorefractor, non-cycloplegic skiascopy). The assumed specificity of the tests was 90%, while the sensitivities ranged from 42% to 64%, and the positive predictive values were between 11% and 17%. Since the positive predictive value of each individual test was so low, the authors concluded that “screening using only one test cannot be recommended without reservation. Combinations of tests or multiple-stage examinations may be more beneficial.” (9) Further studies need to explore which combinations of tests, if any, might be beneficial.

Because of the lack of conclusive evidence regarding the effectiveness of eye screenings, it is also important to evaluate the quality of data and basis for conclusions that are described in research studies.  Studies usually do not assess the number of under-referrals, which means that it is largely unknown how many children with visual issues were not referred for a complete eye exam by an eye doctor.(10) In addition, a review published by the Cochrane Collaboration in 2009 concludes that “despite the large amount of literature available regarding vision screening, no trials designed to compare the prevalence of amblyopia in screened versus unscreened populations were found.” (11)

Visual Acuity Screenings: Challenges and Failures

Ineffectiveness of Visual Acuity Screenings

Since impaired visual acuity is common in older adults, it is important to be able to identify those with impaired vision in order to provide interventions. However, studies have found that screening for impaired visual acuity in primary care settings (i.e. doctor's offices) in adults older than 65 was not effective. “Direct evidence from three fair-quality cluster randomized trials (N=4,728) found vision screening as part of multi-component primary care intervention associated with no benefits.” (12) Moreover, another study found that visual acuity “screening by an ophthalmologist in frail older adults is associated with an increased risk of falls and a trend towards increased risk of fractures.”(13)

Another problem with visual acuity screenings is that they fail to detect children who have reading problems, hyperopia or astigmatism. A study conducted in Sydney, Australia, with 12-year-old-children found that though visual acuity screening was effective in detecting myopia with high sensitivity and specificity, it was not reliable in detecting hyperopia or astigmatism. Children who had high degrees of hyperopia (>5 diopter) and astigmatism (>1.5 diopter) were still able to read a 6/6 (20/20) Snellen equivalent on the eye chart. Children are often able to accommodate uncorrected hyperopia temporarily, but this ability likely reduces with increasing age. Since children usually experience decreasing amounts of their hyperopic refractive error with increasing age, it is likely that most of the adolescents in the study had an even larger hyperopic refractive error as toddlers. (14) Though schools currently address myopia in screening programs, most fail to screen for specific visual skills that might affect the ability of a student to read. A study was conducted among high school students in California who were identified by their teachers as "poor readers." The study found that only 17% of the students had deficient visual acuity (20/40 or worse in one eye), but 80% of the students were inadequate or weak in at least one of the following visual skills: binocular fusion ranges at near, accomodative facility, and convergence near point. Stated another way, 80% of the students passed the visual acuity testing, but only 20% had adequate visual skills. “Given that distance visual acuity is not generally associated with reading difficulties, the apparent disconnect between acuity and visual skills in this study is not surprising.”(15) In fact, the literature suggests that myopic refractive error is associated with good reading, while hyperopic error is associated with poor reading. Because measures of visual acuity typically used in school screenings tend to reveal myopia (near-sightedness) and not hyperopia (far-sightedness), students who are at risk for reading problems caused by hyperopia will be missed.(16)

Various screening tests have been developed in an attempt to maximize correct referrals, reduce over referrals, and identify children with visual problems. The SUNY State College of Optometry developed a screening course and educational program for use in New York City Public Schools. The screenings, which were administered by trained second-year medical interns, go above and beyond the mandated New York City requirements of distance and near visual acuities, +2.00 hyperopia test, color vision testing, and stereopsis testing for students. The interns were required to attend a 3-hour orientation and pass a practical examination that demonstrated their proficiency in the screening tests. They utilized the clinical skills that they had learned during their first year of clinical training. The screening process was comprehensive and also included a brief history, retinoscopy, cover test, near point of convergence, extraocular motilities, amplitude of accommodation, and direct ophthalmoscopy. Using these various tests, 1,992 children were screened, and a total of 601 (30%) were referred for a comprehensive eye examination by an eye doctor. The study conclusively determined that screenings should not only test distance visual acuity. Of the 601 children referred in the study, 249 (41%) passed the distance visual acuity tests, but were still referred for other reasons. Though results from various studies document that less than half of the children with clinically significant visual disorders were identified with distance visual acuity tests alone, distance visual acuity unfortunately remains one of the most widely used screening tests. If the screening test in the New York City Public Schools had solely consisted of distance visual acuity, only 19% of the children screened would have been referred for further care, as opposed to the 30% referred by the SUNY intervention. Screening solely for reduced distance visual acuity may miss up to 40% of children with potential vision problems, including hyperopia, binocular disorders, or other ocular health problems.(17) While vision screenings are typically provided by nurses, students, or others without comprehensive clinical ophthalmology training (i.e. laypersons), the tests provided in the New York City Public Schools required advanced clinical ophthalmic training.

There is further evidence that visual acuity screening is largely ineffective. A study conducted in 1998 found that retinoscopy was a more sensitive test than visual acuity testing. In this study, 95% of the children who failed retinoscopy, compared with 52% of children who failed a visual acuity test, were confirmed to have a visual problem. These results, therefore, suggest that an objective test such as retinoscopy is more sensitive than a subjective test such as visual acuity.(17) The results coincide with the fact that retinoscopy does not only detect myopia, but it also detects hyperopia and astigmatism even when visual acuity is normal. Additionally, retinoscopy requires advanced clinical ophthalmic training, and it cannot be conducted by students, nurses, or laypersons.

Vision Screening Results Vary Based On Screener

An additional problem with visual acuity screenings is that the results can vary based on who conducts the screening, the type of training provided, and the protocol employed. A study analyzed vision screenings among three and four year old preschool children in the United States. The screenings occurred in community-based and primary care settings. Referral rates in community-based screenings were 31% in 3-year-olds, and 28% in 4-year olds, while in primary care settings, referral rates were 4% in 3-year-olds, and 5% in 4-year olds. Though it is unclear why such a discrepancy was observed, it is possible that health care professionals are able to provide a more accurate screen, compared with community volunteers. This discrepancy in referral rates warrants additional consideration and research.(17) A study on SureSight vision screener found a similar relationship between experience of those screening and the referral rate. In this case, the referral rate decreased as the volunteers gained more experience. These volunteers showed a marked decrease in referral rate with time, and all three screeners eventually reached a referral rate of approximately 7%. The average initial referral rate was 10.6%(18) While neither of these studies assessed the sensitivity, specificity, or positive predictive values of the screeners, these studies reveal that vision screenings are largely subjective and can be inaccurate since the results vary considerably based on the screener.

Differences in visual acuity screenings can also be attributed to varying guidelines and protocols. Even within the United States, there are widespread differences regarding pre-school vision screening guidelines. The American Academy of Ophthalmology (AAO), American Association for Pediatric Ophthalmology and Strabismus (AAPOS), and the American Academy of Pediatrics (AAP) all recommend that vision screening be performed on children between the ages of 3 and 3 ½ years.  However, though these recommendations do exist, current practices are non-standardized and vary by state and locality.(19)

The Unreliability of School Screenings

Similarly, an Israeli study conducted by Liora Ore estimated the reliability of the E-chart for vision testing when used by school nurses. “The underlying assumption is that early detection of vision abnormality can lead to early intervention followed by optimal student functioning. Despite the widespread use of vision testing, only a few investigators reported its reliability among school-age children. Some researchers reported reliability data mainly as a quality-assurance aspect integral to their projects.” (20)  Taking this into account, Ore’s study examined the reliability of vision testing by school nurses. Because “no gold standard exists within the school setting,” the goal of the study was to assess the reliability of vision screening by determining the differences in results between two nurses. Of the 751 students in the study, 649 (86.4%) had similar recommendations by both nurses.  For the remaining 13.6%, the results by the nurses did not correspond. The study mentions three potential explanations: “(a) lack of constancy (the vision changed between the two measurements); (b) lack of precision (the testing procedure yielded variable results); and (c) lack of objectivity (the nurses differed in the way they performed and recorded the vision measurements).” The study emphasizes that it is unlikely that a real change in the student’s vision occurred between the two vision screenings. The study explains that lack of constancy may be due to other influences on the student's response such as motivation, as well as the nurse's appearance and manner. In addition, “lack of precision of the measurement procedure or lack of objectivity cannot be ruled out because of variations in the nurses’ skills or their propensity for making mistakes.” (21) The findings from this study reveal the lack of reliability of the screening test. This is important because an unreliable measure can produce false negatives and false positives, which each have their own clinical consequences.(22)

Screening is oftentimes considered the first step in identifying and later treating children with vision disorders. Once identified through a screening program, these children require effective follow-up care. “A thorough analysis of any screening program demands gold-standard comparisons both for children who are referred and at least a proportion of the children who pass the screening.” (23)  Due to the high costs, programs rarely collect examination and treatment results from referral eye care specialists. This is problematic because when studies fail to take into account subsequent examination and treatment results, they have no accurate information concerning the number of false negatives, or the cases that were missed.(24) “It is important to remember that vision screenings are not comprehensive examinations.” (25) The low referral rates from primary care practices and the low follow up rates also suggest the need for educating primary care-based health care providers, parents(26), teachers, and others about the realities of vision screenings.

Another issue is the varying ways that vision screeners deal with children who are unable to complete the screenings. The Vision in Preschools Study focused on the prevalence of ocular conditions among children who were unable to perform preschool vision tests. The study found that children who were unable to perform a visual acuity test were more likely to have vision disorders than those who passed the test. “In practice, children who are unable to perform a screening test are often not referred for a comprehensive eye examination, and they are managed as a child who has passed the screening… However, those who are unable to perform a test are at higher risk of having a targeted condition than are children who perform the test and pass it.”(27) The results of this study suggest that when a child is unable to complete a visual acuity test, it is important to refer the child to an eye doctor. This is not part of regular practice, however.

Vision screenings frequently believe that children with eyeglasses have received necessary eye care. However, a study conducted in New York City found that “with the glasses, 80 of the 163 children (49%) failed the screening: 65 children (81%) failed a test of visual acuity, 3 children (16%) failed for binocularity (and passed visual acuity), and 2 children (2.5%) failed for reported symptoms. Of the non-eyeglass-wearing children, 521 of 1,829 (28%) failed the screening. When comparing children who were wearing glasses with those who did not wear glasses, children who wore glasses were more likely to be referred than children who did not wear glasses. ” (28)  Thus, it cannot be assumed that those with eyeglasses have recently received a necessary eye exam.

It is also important to take into account societal and cultural factors when conducting screenings and assessing vision. Studies have found that children who reside in lower socioeconomic areas are more susceptible to poverty, malnourishment, and negative eye and visual health consequences than their peers in higher socioeconomic areas. One study compared the failure rates for a vision screening performed on children from a higher socioeconomic area with children residing in a lower economic area and found that those from lower economic areas were more likely to fail the screening, with a ratio of 38% versus 24%.(29) Thus, it is especially important that these children receive follow up care. Prior reports on vision screenings in minority children found that they were less likely to receive follow-up care. A study conducted at the University of Michigan found that “non-Hispanic and non-black children were 47% more likely than Hispanic children and 59% more likely than black children to have received eye care in the last year.  The author of the study suggested that cultural and social barriers, parent and teacher perceptions, and insurance issues contribute to the above disparity.” (30) It is important to recognize these disparities, so that eye care can be targeted to those under-served populations.

Challenges and Failures of Photoscreeners

It is important to distinguish between diagnostic tests and screening tests. A screening test is intended to identify those with a given problem, though research indicates that screenings are frequently not effective. There is no requirement for a screening test to quantify the extent of a deficit. In contrast, a diagnostic test by an eye care professional (i.e. a comprehensive eye exam) is intended to identify and quantify the severity of a condition.

Photoscreening is a screening test used to detect refractive error, but it does not diagnose the extent of the refractive error (this would be achieved through a diagnostic test called refraction). Though the photoscreener is intended to detect refractive area, and may detect an amblyogenic factor, it may not detect amblyopia itself. Strabismus may also be detected, but the sensitivity and specificity rates are much lower than those of detecting refractive error.(31)

Early detection and treatment of refractive error in children is critical for treating amblyopia, a disorder that can lead to permanent visual loss.  Thus, photoscreeners have been designed to evaluate uncorrected refractive error in children. Though sensitivity in detecting amblyopia among the different photoscreeners ranges from 63% to 98%, it is important to realize that in creating a tool with very high sensitivity, there will be an accompanying increase in false-positive rate and higher rate of referral of unaffected children. A screening program in Iowa which used the MTI PhotoScreener found that over the 9 years that the program was implemented, the overall positive predictive value was found to be 94.2%, and the estimated sensitivity was 52.4%. This sensitivity was lower than the known sensitivity of the photoscreener and may indicate that the screening program “failed to detect as many children with amblyopic risk factors as [they] identified.”(32) Moreover, a study which compared 11 preschool vision screening tests found that at 90% specificity, the sensitivities of the Retinomax Autorefractor (63%), SureSight Vision Screener (63%), Lea Symbols test (61%), Power Refractor II (54%), HOT VA test (54%), Random Dot E steroacuity (42%) and Stereo Smile II (44%) were all higher than the MTI and iScreen photoscreener, which had 37% sensitivity.(33) Thus, using photoscreeners in screenings may not be the most effective way to detect amblyopic risk factors. “The variable sensitivities, difficulty in comparisons among photo-screening tools, and lack of an established track record for these technologies have made their acceptance among screening practitioners suboptimal.” For this reason, “the American Academy of Pediatrics and the American Association for Pediatric Ophthalmology and Strabismus continue to recommend an eye chart–based vision test in the clinician's office for children aged 3 years or older as the standard of care for vision screening.”(34)

Though there is overwhelming evidence that amblyopia can be treated by an eye doctor once the condition is detected, there is no consensus regarding the best way to screen children. Some believe that objective screening technologies, such as photoscreeners, are effective at detecting the most common causes of visual impairment in children. However, professional organizations have been more reluctant to embrace these technologies. For example, the American Academy of Pediatrics, in a position statement, called “photo screening an innovative tool which needs additional research.” (35) The only sure way to detect amblyopia, or any visual impairment, is to ensure that children and adults receive a complete eye exam by an eye doctor. Eye care is provided through most health insurance programs in the U.S., including private insurances, Children's Health Insurance Program (CHIP), VisionUSA, and EyeCare America. In Canada, eye exams are covered by the governmental health insurance for those under the age of 18 and over the age of 65. Canadians may also access free eye care if they have a complaint that needs examination and diagnosis (i.e. not a check-up).

Conclusion

Though vision screenings are commonly implemented and frequently believed to be an effective way to detect visual problems and impairments, they are largely ineffective. At their best, visual acuity screenings are only able to detect visual impairments that impact distance vision. Even if a community member truly does not have a visual impairment that affects distance vision, they could have other eye conditions that need to be diagnosed and treated by an eye doctor, such as cataracts, glaucoma, diabetic retinopathy, etc. Therefore, anyone who receives a visual acuity screening must still be referred to an eye doctor for a complete eye exam. It is also important that one not be told that they have "passed" a vision screening. If this type of message is communicated to a child or adult, they may be under the incorrect impression that they received an eye exam, and therefore they would unfortunately believe that they do not need to seek comprehensive eye care by an eye doctor. Therefore, all who "pass" a visual acuity screening still need to be urged to have regularly scheduled eye exams by eye doctors. A cursory screening will not provide the community member with the essential comprehensive exam, diagnosis, or treatment that they need. An educational message must be promoted in communities about the need for comprehensive eye exams by eye doctors.

Footnotes

(1) Hård, A., “Results of vision screening of 6-year-olds at school: a population-based study with emphasis on screening limits.” Acta Ophthalmologica Scandinavica. 85. (2007): 415-418. Accessed on 13 October 2010.

(2) Carlton, J., and Czoski-Murray, C. “The Value of Screening for Amblyopia Revisted.” Accessed on 15 October 2010.

(3) Oleske, D. “Screening and Surveillance for Promoting Population Health.” Epidemiology and the Delivery of Health Care Services. (2009). Accessed on 13 October 2010.

(4) Lagrèze, W. “Vision Screening in Preschool Children. Do the Data Support Universal Screening?” Deutsches Arzteblatt International. 107. 28-29. (2010); 495-499. Accessed on 14 October 2010.

(5) Oleske, D. “Screening and Surveillance for Promoting Population Health.” Epidemiology and the Delivery of Health Care Services. (2009). Accessed on 13 October 2010.

(6) Evans, J., Smeeth, L., and Fletcher, A. “Vision Screening.” British Journal of Ophthalmology. 93 (20090: 704-705. Accessed on 13 October 2010.

(7) Ibid.

(8) Lagrèze, W. “Vision Screening in Preschool Children. Do the Data Support Universal Screening?” Deutsches Arzteblatt International. 107. 28-29. (2010); 495-499. Accessed on 14 October 2010.

(9) Ibid.

(10) Hård, A., “Results of vision screening of 6-year-olds at school: a population-based study with emphasis on screening limits.” Acta Ophthalmologica Scandinavica. 85. (2007): 415-418. Accessed on 13 October 2010.

(11) Lagrèze, W. “Vision Screening in Preschool Children. Do the Data Support Universal Screening?” Deutsches Arzteblatt International. 107. 28-29. (2010); 495-499. Accessed on 14 October 2010.

(12) Chou, R., Dana, T., and Bougatsos, C. “Screening for Visual Impairment in Older Adults: Systematic Review to Update the 1996 U.S. Preventive Services Task Force Recommendation.” Accessed on 14 October 2010.

(13) Ibid.

(14) Bradfield, Y. JAMA. “Use of Visual Acuity to Screen for Significant Refractive Errors in Adolescents: Is It Reliable?’ 304.10 (2010): 1114-1115. Accessed on 14 October 2010.

(15) Grisham, D., Powers, M., and Riles, P. “Visual skills of poor readers in high school.” Journal of the American Optometric Association. 78.10 (2007); 542-549. Accessed on 14 October 2010.

(16) Ibid.

(17) Bodack, M., Chung, I., and Krumholtz, I. “An Analysis of Vision Screening Data from New York City Public Schools.” Journal of the American Optometric Association. 81.9 (2010); 476-484. Accessed on 15 October 2010.

(18) Hartmann, E., et. al. “Project Universal Preschool Vision Screening: A Demonstration Project.” Pediatrics. 117.2 (2006): 226-237. Accessed on 14 October 2010.

(19) Rowatt, A. “Field evaluation of the Welch Allyn SureSight Vision Screener: Incorporating the Vision in Preschoolers study recommendations.” Journal of American Association for Pediatric Ophthalmology and Strabismus. 11.3 (20070: 243-248. Accessed on 14 October 2010.

(20) Carlton, J., and Czoski-Murray, C. “The Value of Screening for Amblyopia Revisted.” Accessed on 15 October 2010.

(21) Ore, L., Tamir, A., Stein, N., and Cohen-Dar, M. “Reliability of Vision Screening Tests for School Children.” Journal of Nursing Scholarship. 41.3 (2009): 250-259. Accessed on 15 October 2010.

(22) Ibid.

(23) Ibid.

(24) Hartmann, E., et. al. “Project Universal Preschool Vision Screening: A Demonstration Project.” Pediatrics. 117.2 (2006): 226-237. Accessed on 14 October 2010.

(25) Ibid.

(26) Bodack, M., Chung, I., and Krumholtz, I. “An Analysis of Vision Screening Data from New York City Public Schools.” Journal of the American Optometric Association. 81.9 (2010); 476-484. Accessed on 15 October 2010.

(27) Hartmann, E., et. al. “Project Universal Preschool Vision Screening: A Demonstration Project.” Pediatrics. 117.2 (2006): 226-237. Accessed on 14 October 2010.

(28) “Children Unable to Perform Screening Tests in Vision in Preschoolers Study: Proportion with Ocular Conditions and Impact on Measures of Test Accuracy.” Investigative Ophthalmology and Visual Science. 48 (2007):83-87. Accessed on 14 October 2010.

(29) Bodack, M., Chung, I., and Krumholtz, I. “An Analysis of Vision Screening Data from New York City Public Schools.” Journal of the American Optometric Association. 81.9 (2010); 476-484. Accessed on 15 October 2010.

(30) Ibid.

(31) Ibid.

(32) Carlton, J., and Czoski-Murray, C. “The Value of Screening for Amblyopia Revisted.” Accessed on 15 October 2010.

(33) Longmuir, S., Pfeifer, W., Leon, A., Olson, R., Short, L., and Scott, W. “Nine-year Results of a Volunteer Lay Network Photoscreening Program of 147,809 Children Using a PhotoScreener in Iowa.” Ophthalmology. 117.10 (2010): 1869-1875. Accessed on 18 October 2010.

(34) Schmidt, P., et. al. “Comparison of Preschool Vision Screening Tests as Administered by Licensed Eye Care Professionals in the Vision in Preschoolers Study.” Ophthalmology. 111. 4 (2004): 637-50. Accessed on 18 October 2010.

(35) Bradfield, Y. JAMA. “Use of Visual Acuity to Screen for Significant Refractive Errors in Adolescents: Is It Reliable?’ 304.10 (2010): 1114-1115. Accessed on 14 October 2010.

(36) Donahue, Sean. “Objective Vision Screening for Amblyopia in Children: A Test That Has Finally Arrived.” Ophthalmology. 117.10 (2010): 1867-1868. Accessed on 18 October 2010.